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Accession IconGSE31086

Expression data from Bmi1-null common myeloid progenitor (CMP)

Organism Icon Mus musculus
Sample Icon 6 Downloadable Samples
Technology Badge Icon Affymetrix Mouse Genome 430 2.0 Array (mouse4302)

Submitter Supplied Information

Description
Bmi1 is a component of polycomb repressive complex 1 and its role in the inheritance of the stemness of adult somatic stem cells has been well characterized. Bmi1 maintains the self-renewal capacity of adult stem cells, at least partially, by repressing the Ink4a/Arf locus that encodes a cyclin-dependent kinase inhibitor, p16Ink4a, and a tumor suppressor, p19Arf 14. Deletion of both Ink4a and Arf in Bmi1-deficient mice substantially restored the defective self-renewal capacity of HSCs and neural stem cells.
PubMed ID
Total Samples
6
Submitter’s Institution
Alternate Accession IDs

Samples

Show of 6 Total Samples
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Title
Specimen part
Processing Information
Additional Metadata
DKO CMP2
common myeloid progenitor (cmp)
WT CMP2
common myeloid progenitor (cmp)
TKO CMP1
common myeloid progenitor (cmp)
TKO CMP2
common myeloid progenitor (cmp)
DKO CMP1
common myeloid progenitor (cmp)
WT CMP1
common myeloid progenitor (cmp)
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