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Accession IconGSE75888

Expression data for iPSC-derived hepatocyte-like cells (HLCs) treated with 100 M pazopanib for 24 hours

Organism Icon Homo sapiens
Sample Icon 25 Downloadable Samples
Technology Badge Icon Affymetrix Human Genome U133 Plus 2.0 Array (hgu133plus2)

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Description
Pazopanib is a drug with idiosyncratic hepatotoxicity risk. Analysis of gene expression changes after exposing hepatocytes can indicate effects on specific biological pathways and potential mechanisms of hepatotoxicity. HLCs derived from patient-specific iPSCs were treated with pazopanib to identify both drug-related global effects and patient-specific effects
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Total Samples
29
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GSM1969449
HT2 - pazopanib_24 h, biological rep 1
GSM1969450
HT2 - pazopanib_24 h, biological rep 2
GSM1969464
NHT2 - DMSO_24 h, biological rep 2
GSM1969467
NHT2 - pazopanib_24 h, biological rep 2
GSM1969452
HT3 - DMSO_24 h, biological rep 1
GSM1969461
NHT1 - pazopanib_24 h, biological rep 2
GSM1969468
NHT2 - pazopanib_24 h, biological rep 3
GSM1969453
HT3 - DMSO_24 h, biological rep 3
GSM1969446
HT2 - DMSO_24 h, biological rep 1
GSM1969443
HT1 - pazopanib_24 h, biological rep 1
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